Objective: To investigate and analyze the effect of continuous hemodiafiltration high dose and conventional dose on the curative effect and inflammatory factors of severe pancreatitis. Methods: One hundred and twelve patients with severe pancreatitis admitted to our hospital from May 2019 to August 2021 were opted and randomly divided into two clusters, with the control cluster receiving conventional dose of continuous haemodialysis filtration healing and the study cluster receiving excessive dose of continuous haemodialysis filtration healing. Results: Contrasted with the control cluster, the clinical healing effect of the study cluster was better (P<0.05); after healing, contrasted with the control cluster, the clinical indicators of the study cluster were better (P<0.05); Before healing, none notable variation in the levels of inflammatory factors between the two clusters (P>0.05). After healing, contrasted with the control cluster, the levels of CRP, TNF-α, PCT, AMY and Scr within the study cluster were bottom (P<0.05); Before healing, none notable variation in serum phosphorus, albumin and cholesterol between the two clusters (P>0.05), the albumin and cholesterol levels of the research cluster were upper (P<0.05); Contrasted with the control cluster, the life marks within the study cluster were upper (P<0.05); Contrasted with the control cluster, the body temperature, heart rate, respiratory vital signs within the study cluster were bottom than those in the control cluster, and the variations between the clusters were notable (P<0.05); After 0h~120h after operation, the APACHE II marks of the two clusters were notably decreased. Conclusion: Continuous hemodiafiltration, as an effective healing method, is used in the healing of severe pancreatitis. The increase in the dose of diafiltration can greatly enhance the healing effect of patients with severe pancreatitis, and further optimize the gastrointestinal decompression and drainage volume, etc. Various clinical indicators, optimization of various inflammatory factor indicators and enhancement of blood phosphorus, albumin and cholesterol indicators in the body can greatly enhance the life mark of patients, and promote patients to basically recover various skills in a short time.