Purpose: To explore the impact of safety management on the perioperative psychological well-being and well-being of fitness players undergoing cardiac interventions. Methods: In our hospital, 294 fitness players who underwent cardiac intervention from June 2019 to January 2022 were divided into 2 groups according to the different care modalities, with those undergoing routine care being the control group and those undergoing safety management being the study group. The two groups were compared for improvement of negative emotions, quality of life, complications, cardiac function, satisfaction, and nursing effects. Results: Before taking into account, there was no huge contrast on sas and sds scores between the 2 groups (p>0.05), and in any case, after taking into account, there was a profound critical decrease in sas and sds points in both groups,However, in this comparison, the decrease in the research group was clearly greater than that of the study group (p<0.05), and the quality of life experience difference was not very significant for the two groups before the care was provided. Before care, the two groups were compared and no significant difference was found in the quality of life experience of the respective fitness players (p>0.05), but after systematic care, the marks of personal satisfaction achieved by the tandem groups did not increase very significantly, The comparison revealed that the improvement in the study group was more noteworthy than the comparison group (P<0.05); it was learned that the two-point extent of improvement in the study group was 96.23%, higher than the comparison group (96.35%), and the comparison between the above both groups was statistically significant;In the study comparison of complications, it was found that the probability of the study group was 3.52% less than that of the comparison group (8.55%). However, before the care, there was no highly noticeable improvement in cardiac function between the two groups (P>0.05), on the other hand, after the care, the improvement in cardiovascular function was significantly larger in the study group than in the comparison group (P<0.05).; There was no obvious comparison between the nature of care and nursing error scores of the groups before nursing care was performed (P>0. 05), while after nursing care, the nature of care and nursing error scores of both groups basically improved, although the increment of the difference was greater in the study group than in the comparison group, and the degree of improvement was more significant (P<0. 05). Conclusion: Nursing safety management plays an important role in the perioperative care of fitness players undergoing cardiac interventions, contributing to improved mental health and quality of life, and with good patient prognosis. Therefore, the nursing management approach is worth promoting and applying.