The main content of this study is the important value and prospect of using bone substitute materials in orthopedic trauma repair. Firstly, the biocompatibility of bone substitute materials is reviewed. The evaluation methods of biocompatibility of bone substitute materials mainly include in vivo biological research and in vitro biological research. At the same time, it is also analyzed that bone substitute materials have important influence on the internal environment, including the influence on cell morphology and cell function. Combined with the above analysis, based on the spiral CT image data, assisted by computer technology, a personalized bone substitute was made. It is found that the bone materials designed according to the above methods have good matching, and when implanted in the wound repair site, it will not cause great trauma during the operation, and it can also save the operation time. At the same time, after the follow-up of patients, it is found that the artificial bone materials have very significant compatibility and high safety. Therefore, bone substitute materials made by combining CT imaging technology, computer technology and the actual clinical manifestations of patients can play a significant therapeutic effect in the process of wound repair, which is worthy of clinical application.