Objective: The research aims to determine the impact of high-Altitude training on athletic performance in Andean athletes. Using the distinct physiological adaptations that people who live in high-altitude areas have evolved, this study examines the effects of high-altitude training on the athletic performance of Andean athletes. This study investigates Andean athletes' baseline physiological characteristics (red blood cell count, oxygen saturation, and lung capacity). An organized high-altitude training program aims to evaluate the impact of altitude on strength, cardiovascular endurance, and overall athletic performance. Working with geneticists, the research explores genetic variables that affect Andean athletes' capacity to adjust to training at high altitudes. For measuring, the research used SPSS software and generated results including descriptive statistics, correlation coefficient, the model summary, and chi-square analysis between the independent and dependent. The purpose of the study is to record any negative effects that participants may have experienced as well as any potential benefits and difficulties related to purposeful high-altitude training. The results have the potential to improve training protocols, guide customized strategies based on genetic profiles, and advance the conversation on the moral ramifications of exceeding human potential in the sake of sports achievement. The overall result found a positive impact of high-altitude training on athletic performance in Andean athletes. This research aims to further our understanding of the intricate interactions between purposeful training, innate abilities, and athletic performance in demanding settings.