The objective of this study was to analyze the effect of altitude on physical performance in professional soccer players during matches played in Liga MX according to somatotype. Twenty-nine professional soccer players were evaluated, classified by somatotype, and aerobic and anaerobic variables were measure in the regular competitive phase through the WIMU GPS device. Sports performance was related to the altitude of the place where they played. No differences were find according to the somatotype of the players. In the performance component, significant correlations were find for the variables of acceleration of 3m / s2 and 2m / s2, deceleration of 3m / s2, intensity, and metabolic load based on the games played at the highest altitude. The physical performance of the players is affected in anaerobic processes according to the altitude during the matches when the execution of game actions with higher intensity is required.