The aim of this study was to contrast the effects of two different types of fatigue, local and general, on knee proprioception. Twenty two male amateur soccer players were evaluated on isokinetic dynamometer before and after exercise induced both local and general fatigue. This evaluation consisted of an active knee repositioning test, in which mean absolute and relative deviations regarding target angle (30º knee flexion) were assessed. The proprioceptive capacity of the subjects was affected by induction of both types of fatigue only when mean absolute error was estimated; however, no statistical differences were found between them. In conclusion, and regardless of their type, fatigue induced to these players seems to influence the proprioception of the knees although this effect is dependent on the type of angular error that is considered.