Objective: To investigate the effect of vacuum sealing drainage (VSD) in the healing of adult orthopedic wound infection, and to explore the effect of intervention on white blood cell (WBC) and C-reactive protein (CRP) levels; Methods: 80 adult Athlete patients with orthopedic wound infection who were healed in our hospital from January 2020 to January 2022 were retrospectively opted as the research subjects, and were divided into the VSD cluster (n=40, receiving VSD technology) and the control cluster according to their healing methods (CG, n=40, receiving conventional gauze dressing healing), the variations in WBC and CRP between the two clusters before healing, on the 5th day of healing, on the 10th day of healing, and on the 15th day of healing were contrasted between the two clusters, and the wound surfaces of the two clusters of athlete patients were contrasted at the above time points. The variation in appearance, the variation in the bacterial negative rate of the wound surface after the intervention was contrasted, and the wounded limb marks of the two clusters of athlete patients were followed up; Results: (1) On the 5th day, 10th day and 15th day of healing, the WBC and CRP levels in the VSD cluster were notably lower than those within the control cluster (P < 0.05); (2) On the 5th day, 10th day and 15th day of healing, the wound appearance marks in the VSD cluster were notably upper than those within the control cluster, and the variation between the clusters was notable (P < 0.05); (3) The wound bacterial conversion rates within the study cluster were 40.00%, 70.00% and 95.00% at 1 month, 2 months and 3 months after operation, respectively, which were notably upper than 17.50%, 47.50% and 80.00% within the control cluster, and the variation between the clusters was notable (P < 0.05); (4) At 1 month, 2 months and 3 months after operation, the Puno limb marks within the study cluster were notably upper than those within the control cluster, and the variation between the clusters was notable (P < 0.05); Conclusion: VSD technology has a good effect on the healing of adult orthopedic wound infection, can notably enhance the athlete patient's inflammatory state, notably enhance the bacterial negative rate of the patient's wound, help to speed up the patient's recovery process, and has positive sense for the athlete patient's wound recovery.