The interactions between hypoglycemic drugs and other drugs were retrieved based on the pharmacy information database to evaluate the X-level/contraindication and D-level/serious potential drug interactions (pDDIs) of outpatient anticoagulant prescriptions, so as to provide a guarantee for clinically safe drug use. METHODS: Based on the interaction of 5 oral anticoagulants recommended in the "China Guidelines for the Prevention and Treatment of Thrombotic Diseases (2018 Edition)" retrieved from the two databases of Lexicomp and Micromedex, statistics of a hospital from January 1,2021 to 2022 During March 31st,200 outpatients with anticoagulant prescriptions for grade X/contraindication and grade D/severe pDDIs were analyzed by multivariate Logistic binary regression analysis. RESULTS: Among the 200 athletic patients, there were 0 pairs of grade X/taboo pDDIs,and 67 pairs of grade D/severe pDDIs, mainly due to grade D/serious potential bleeding caused by the combination of anticoagulants and non-steroidal anti-inflammatory drugs(NSAIDs) risk. Multivariate Logistic binary regression analysis found that multiple drug combination (≥5 kinds) and concomitant cardiovascular disease were risk factors for the occurrence of grade D/severe pDDIs. CONCLUSION: for athletic patients with multiple diseases coexisting and needing to take multiple drugs, it is necessary to pay attention to the pDDIs of anticoagulant drugs, select appropriate drugs, and avoid fatal risks such as severe bleeding. Adverse reactions after medication were closely monitored.