Objective: A cohort study was carried out to research the effects of integrated holistic nursing model on the success rate, complications and cooperation of athletic patients undergoing cardiac surgery. Methods: During June 2019 to August 2021, 80 athletic patients who went through cardiac surgery were enrolled in our hospital as the research objects. A random number table method was used to divide the athletic patients into a control and a research group, each with 40 cases. The control group adopted the traditional medical work mode, and research group adopted the holistic nursing model of integrated medical and nursing care. The nursing satisfaction, the degree of cooperation between doctors and nurses, the success rate of operation, the incidence of complications, the improvement of cardiac function, sleep quality and life quality were compared. Results: In terms nursing satisfaction, the study group was very pleased in 26 players , satisfactory in 16 players and general in 8 players , with a satisfaction rate of 100.00%; In the control group, 15 players were very pleased, 10 players were pleased, 7 players were general, 8 players were displeased, and the satisfaction rate was 80.00%; The nursing satisfaction of the study group was higher (P<0.05). Compared with the degree of cooperation between doctors and nurses, the scores of factor 1, factor 2 and factor 3 in the study group were noticeably higher (P<0.05). Regarding the success rate of operation and the incidence of complications, the success rate of operation in the study group was higher, and the incidence of complications in the study group was lower (P<0.05). With regard to the success rate of operation and the incidence of complications, the success rate of operation in the study group was higher, and the incidence of complications in the study group was lower (P<0.05). In terms of the improvement of cardiac function indexes, there exhibited no noticeable difference (P>0.05); Six months after operation, the level of left ventricular ejection fraction (LVEF) in the study group was noticeably higher than that in the control group, while the left ventricular end-diastolic diameter (LVEDD) and plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in the study group were noticeably lower (P<0.05). Compared with the sleep quality scores, there exhibited no noticeable difference (P>0.05); Six months after operation, the scores of sleep quality, falling asleep time, sleep efficiency, sleep disorder and daytime dysfunction in the study group were lower (P<0.05). There exhibited no noticeable difference in preoperative life quality scores (P>0.05); Six months after operation, the scores of physiological functions, body pain, overall health, vitality, social function, emotional function and mental health in the study group were noticeably higher (P<0.05). Conclusion: The integrated holistic nursing model can enhance the success rate of cardiac surgery, reduce the incidence of complications, further promote the cardiac function and sleep quality, strengthen the life quality of athletic patients , and help athletic patients return to family and society as soon as possible. The integrated holistic nursing model of health care also promotes harmonious relationships between doctors and nurses and cooperative behavior between them.