Objective: To examine the effect of family follow-up education on anxiety and depression, quality of life, and self-efficacy for rational medication use in school-aged athletic children with epilepsy after discharge. Methods: A total of 100 school-age athletic children with epilepsy who were admitted to the Defiantly improved compared with the control group, the anxiety and depression were significantly improved, and the quality of life was significantly improved (P<0.05). Conclusion: Family follow-up education for school-age athletic children with epilepsy after discharge from the hospital can significantly improve their rational medication self-efficacy, improve their anxiety and depression, and enhance their quality of life.