AUCUBIN ENHANCES LPS-INDUCED PROLIFERATION AND APOPTOSIS MITIGATION VIA UPREGULATING MICRORNA-9 IN CARTILAGE CELLS: IMPLICATIONS FOR MENTAL AND PHYSICAL HEALTH
Liang A
Department of Second Orthopedics, Affiliated Central Hospital of Shenyang Medical College, shenyang, 110000, china.
Shi Feng
Department of Second Orthopedics, Affiliated Central Hospital of Shenyang Medical College, Shenyang, 110000, China
Di Fu
Department of General Medicine, Affiliated Central Hospital of Shenyang Medical College, Shenyang, 110000, China
Abstract
This research delves into the effects of Aucubin (Au) on LPS-induced inflammation in cartilage cells, with an emphasis on its implications for mental and physical health in osteoarthritis (OA). We analyzed the impact of Au on cell viability, apoptosis, and inflammatory markers, and further explored its regulatory influence on microRNA-9 (miR-9). Our results show that Au effectively mitigates LPS-induced damage in cartilage cells by modulating miR-9, subsequently influencing the NF-κB pathway. This study sheds light on the potential of Au in enhancing both mental and physical health aspects in OA, proposing a novel therapeutic avenue for comprehensive OA management.
Keywords: Aucubin (Au); Osteoarthritis (OA); miR‐9; NF‐κB pathways