Objective: To examine the impact of full-course nursing combined with the Lamaze pain-relieving method on labor duration, pain intensity, and breastfeeding rates in primipara female athletes undergoing natural childbirth. Methods: Between August 2020 and August 2022, 124 primipara female athletes in natural delivery were randomized into a control group (routine nursing) and an observation group (full-course nursing with Lamaze method). Newborn health was assessed using the Apgar score, while pain levels and childbirth self-efficacy were evaluated using pain grading and the Simplified Chinese Childbirth Self-Efficacy Inventory (CBSEI-C32). Variables such as labor duration, breastfeeding outcomes, perineal injury, and postoperative complications were compared between the groups. Results: No significant differences were found in Apgar scores between the groups at 1, 5, and 10 minutes postpartum (P > 0.05). The observation group experienced shorter first and second labor phases and overall labor duration than the control group (P < 0.05). Additionally, the observation group reported lower pain levels (P < 0.05) and higher scores in outcome efficacy, expectation efficacy, and overall CBSEI-C32 (P < 0.05). The cesarean section rate was lower, and the breastfeeding rate was higher in the observation group, with increased lactation volume within the first three days postpartum and shorter initial lactation time (P < 0.05). The observation group also had less severe perineal injuries and a lower rate of episiotomy (P < 0.05). Postoperative complications were fewer in the observation group (P < 0.05). Conclusion: Full-course nursing combined with the Lamaze method significantly benefits primipara female athletes in natural delivery by shortening labor, reducing pain, enhancing self-efficacy, improving breastfeeding rates, minimizing perineal trauma, and reducing postoperative complications. This approach appears to be particularly effective in supporting athletic patients through childbirth.